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OTX008 (b)
CAS No. 1638140-55-2
OTX008 (b)( Calixarene 0118 | PTX-008 )
Catalog No. M12472 CAS No. 1638140-55-2
OTX008 (Calixarene 0118, PTX-008) is a calixarene derivative designed to bind the Galectin-1 (Gal1) amphipathic β-sheet conformation.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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| 500MG | Get Quote | Get Quote |
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Biological Information
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Product NameOTX008 (b)
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NoteResearch use only, not for human use.
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Brief DescriptionOTX008 (Calixarene 0118, PTX-008) is a calixarene derivative designed to bind the Galectin-1 (Gal1) amphipathic β-sheet conformation.
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DescriptionOTX008 (Calixarene 0118, PTX-008) is a calixarene derivative designed to bind the Galectin-1 (Gal1) amphipathic β-sheet conformation; inhibits Gal1 expression and ERK1/2 and AKT-dependent survival pathways, and induces G2/M cell cycle arrest through CDK1; inhibits proliferation and invasion at micromolar concentrations in cancer cells; inhibits growth of A2780-1A9 xenografts in vivo.Solid Tumors Phase 1 Clinical.
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In Vitro——
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In Vivo——
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SynonymsCalixarene 0118 | PTX-008
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetGalectin
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RecptorGalectin
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Research AreaCancer
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IndicationSolid Tumors
Chemical Information
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CAS Number1638140-55-2
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Formula Weight937.18
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Molecular FormulaC52H72N8O8
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical NameAcetamide, 2,?2',?2'',?2'''-?[(2-?methylpentacyclo[19.?3.1.13,?7.19,?13.115,?19]?octacosa-?1(25)?,?3,?5,?7(28)?,?9,?11,?13(27)?,?15,?17,?19(26)?,?21,?23-?dodecaene-?25,?26,?27,?28-?tetrayl)?tetrakis(oxy)?]?tetrakis[N-?[2-?(dimethylamino)?ethyl]?-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Dings RP, et al. J Med Chem. 2012 Jun 14;55(11):5121-9.
2. Astorgues-Xerri L, et al. Eur J Cancer. 2014 Sep;50(14):2463-77.
3. Dings RP, et al. Cancer Lett. 2008 Jul 8;265(2):270-80.
4. Zucchetti M, et al. Cancer Chemother Pharmacol. 2013 Oct;72(4):879-87.
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OTX008 (b)
OTX008 (Calixarene 0118, PTX-008) is a calixarene derivative designed to bind the Galectin-1 (Gal1) amphipathic β-sheet conformation.
